WO/2009/009059 is referenced by 29 patents.

The invention is related to compounds of formula (I) These compounds can be used as antagonists of the TGF-beta family tyle I receptors, Alk5 or Alk4. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e. g. renal fibrosis, pulmonary fibrosis and hepatic fibrosis), progressive cancers or other diseases for which reduction of TGF-beta family signalling activity is desirable.

Title
Spiro compounds as antagonists of tgf-beta
Application Number
PCT/US2008/008401
Publication Number
2009/009059
Application Date
July 9, 2008
Publication Date
January 15, 2009
Inventor
Feng Xiaomei
Lee Wen Cherng
Shan Feng
Niu Deqiang
Sun Lihong
Agent
O BRIEN Jonathan P
Assignee
Feng Xiaomei
Lee Wen Cherng
Shan Feng
Niu Deqiang
Sun Lihong
Biogen Idec Ma
IPC
C07D 471/04
C07D 405/14
A61P 43/00
A61P 35/00
A61K 31/498
A61K 31/437
C07D 401/14
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