WO/2008/081477 is referenced by 4 patents.

Present invention relates to novel 3-aryloxy 3-substituted propanamines of formula (I), method of preparing the same and to their use in inhibiting serotonin and norepinephrine reuptake wherein A is a phenyl which is optionally substituted with up to five substituents; a 1- or 2-naphthyl which is unsubstituted or substituted; a 5-membered heteroaryl radical which contains, as hetero atoms, 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 O- or S-atom, and which is unsubstituted or C-substituted by lower alkyl, phenyl, or substituted phenyl and/or is N-substituted at a N-atom which is capable of substitution by lower alkyl, lower alkoxy and/or halogen; a 2-benzimidazolyl optionally unsubstituted or substituted; and R1 and R2 are each independently hydrogen, C1-6-alkyl, C3-7-cycloalkyl, C3-6-cycloalkyl C1-3-alkyl; or R1 and R2 may together form a C5-7-carbocyclic ring containing 0-2 hetero atoms such as N, O, or S and a salt thereof with a pharmaceutically acceptable acid. Compounds of formula (I) (I-A: R=4-CF3, R1=H, R2=CH3, A=4-fluorophenyl), I-B: R=4-CF3, R1=H, R2=CH3, A=4-methylphenyl, I-C: R=4-CF3, R1=H, R2=CH3, A=4-methoxyphenyl) are found to be better than the antidepressant drug fluoxetine.

Title
3-aryloxy 3-substituted propanamines
Application Number
PCT/IN2008/000001
Publication Number
2008/081477
Application Date
January 2, 2008
Publication Date
July 10, 2008
Inventor
Chowdary Nannapaneni
Venkaiah
Madireddi Umamaheshwar Rao Naidu
Satya Bhujanga Rao
Adibatla Kali
Rajasekhara Reddy Peddi
Yashwant Junnarkar
Ajit
Reddy Muddasani
Pulla
Assignee
Chowdary Nannapaneni
Venkaiah
Madireddi Umamaheshwar Rao Naidu
Satya Bhujanga Rao
Adibatla Kali
Rajasekhara Reddy Peddi
Yashwant Junnarkar
Ajit
Reddy Muddasani
Pulla
Natco Pharma
IPC
C07D 295/092
C07D 211/22
A61P 25/24
A61K 31/5375
A61K 31/452
A61K 31/205
C07C 217/72
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