WO/2007/117410 is referenced by 50 patents.

The invention provides transgene constructs for expressing chimeric antibodies, and transgenic non-human host animals carrying such constructs, wherein the chimeric antibodies comprise human variable regions and constant regions of the non-human transgenic host animal. The presence of immunoglobulin constant regions of the host animal allows for generation of improved antibodies in such transgenic host animals. Subsequently, the chimeric antibodies can be readily converted to fully human antibodies using recombinant DNA techniques. Thus, the invention provides compositions and methods for generating human antibodies in which chimeric antibodies raised in vivo in transgenic mice are used as intermediates and then converted to fully human antibodies in vitro.

Title
Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
Application Number
PCT/US2007/008231
Publication Number
2007/117410
Application Date
March 30, 2007
Publication Date
October 18, 2007
Inventor
Black Amelia
Brams Peter
Tanamachi Dawn M
Agent
GAVIN Kimberley A
Assignee
Black Amelia
Brams Peter
Tanamachi Dawn M
Medarex
IPC
C12P 21/08
A61K 39/00
A01K 67/027
A01K 67/00
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