WO/2006/125293 is referenced by 42 patents.

The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing carrier linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

Title
Derivatives of 4- or 5-aminosalicylic acid
Application Number
PCT/CA2005/000819
Publication Number
2006/125293
Application Date
May 27, 2005
Publication Date
November 30, 2006
Inventor
Fiorucci Stefano
Santagada Vincenzo
Sparatore Anna
Caliendo Giuseppe
Cirino Giuseppe
Wallace John L
Agent
BENNETT JONES
Assignee
Fiorucci Stefano
Santagada Vincenzo
Sparatore Anna
Caliendo Giuseppe
Cirino Giuseppe
Wallace John L
Antibe Therapeutics
IPC
C07D 339/04
C07C 333/02
C07C 327/40
C07C 321/14
A61P 35/00
A61P 29/00
A61P 01/00
A61K 31/67
A61K 31/385
A61K 31/325
A61K 31/27
A61K 31/255
A61K 31/16
C07F 09/6578
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