WO/2006/046024 is referenced by 52 patents.

The invention provides a compound for use as a protein kinase B inhibitor, the compound being a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR5; Jl-J2 is N=C(R6), (R7)C=N, (R8)N-C(O), (R8)2C-C(O), N=N or (R7)C=C(R6); E is a monocyclic carbocyclic or heterocyclic group of 5 or 6 ring members, the heterocyclic group containing up to 3 heteroatoms selected from O, N and S; Q1 is a bond or a saturated C1-3 hydrocarbon linker group, one of the carbon atoms in the linker group being optionally be replaced by an oxygen or nitrogen atom, or an adjacent pair of carbon atoms may be replaced by CONRq or NRqCO where Rq is hydrogen or methyl, or Rq is a C1-4 alkylene chain linked to R1 or a carbon atom of Q1 to form a cyclic moiety; and wherein the carbon atoms of the linker group Q1 may optionally bear one or more substituents selected from fluorine and hydroxy; Q2 is a bond or a saturated hydrocarbon linker group containing from 1 to 3 carbon atoms, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group may optionally bear one or more substituents selected from fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the G group; and provided that when E is aryl or heteroaryl, then Q2 is other than a bond; G is hydrogen, NR2R3, OH or SH provided that when E is aryl or heteroaryl and Q2 is a bond, then G is hydrogen; R1 is hydrogen or an aryl or heteroaryl group, with the proviso that when R1 is hydrogen and G is NR2R3, then Q2 is a bond; and R2, R3, R4, R6 and R8 are as defined in the claims.

Title
Ortho- condensed pyridine and pyrimidine derivatives (e. g. purines) as protein kinases inhibitors
Application Number
PCT/GB2005/004119
Publication Number
2006/046024
Application Date
October 25, 2005
Publication Date
May 4, 2006
Inventor
Donald Alastair
Fonseca Tatiana Faria
Da
Collins Ian
Caldwell John
Wyatt Paul Graham
Woodhead Steven John
Walker David Winter
Saxty Gordon
Boyle Robert George
Berdini Valerio
Agent
HUTCHINS Michael R
Assignee
Donald Alastair
Fonseca Tatiana Faria
Da
Collins Ian
Caldwell John
Wyatt Paul Graham
Woodhead Steven John
Walker David Winter
Saxty Gordon
Boyle Robert George
Berdini Valerio
Cancer Research Technology
The Institute Of Cancer Researchroyal Cancer Hospital
Astex Therapeutics
IPC
C07D 487/04
C07D 473/34
C07D 471/04
A61K 31/519
A61K 31/437
A61K 31/52
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