WO/2006/046023 is referenced by 70 patents.

The invention provides a compound for use in the prophylaxis or treatment of a disease state or condition mediated by protein kinase B, the compound having the formula (I): or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR5; J1-J2 is N=C(R6), (R7)C=N, (R8)N-C(O), (R8)2C-C(O), N=N or (R7)C=C(R6); A is an optionally substituted saturated C1-7 hydrocarbon linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, one of the carbon atoms in the linker group being optionally replaced by oxygen or nitrogen; E is a monocyclic or bicyclic carbocyclic or heterocyclic group or an acyclic group X-G wherein X is CH2, O, S or NH and G is a C1-4 alkylene chain wherein one of the carbon atoms is optionally replaced by O, S or NH; R1 is hydrogen or an aryl or heteroaryl group; R2 and R3 are each hydrogen, optionally substituted C1-4 hydrocarbyl or optionally substituted C1-4 acyl; or NR2R3 forms an imidazole group or a saturated monocyclic heterocyclic group having 4-7 ring members; or NR2R3 and A together form a saturated monocyclic heterocyclic group having 4-7 ring members which is optionally substituted by C1-4 alkyl; or NR2R3 and the adjacent carbon atom of linker group A together form a cyano group; or R1, A and NR2R3 together form a cyano group; and R4, R5, R6, R7 and R8 are each independently selected from hydrogen and various substituents as defined in the claims.

Title
Ortho- condensed pyridine and pyrimidine derivatives (e. g. purines) as protein kinases inhibitors
Application Number
PCT/GB2005/004115
Publication Number
2006/046023
Application Date
October 25, 2005
Publication Date
May 4, 2006
Inventor
Donald Alastair
Fonseca Tatiana Faria
Da
Collins Ian
Caldwell John
Sore Hannah Fiona
Wyatt Paul Graham
Woodhead Steven John
Verdonk Marinus Leendert
Saxty Gordon
Boyle Robert George
Berdini Valerio
Agent
HUTCHINS Michael R
Assignee
Donald Alastair
Fonseca Tatiana Faria
Da
Collins Ian
Caldwell John
Sore Hannah Fiona
Wyatt Paul Graham
Woodhead Steven John
Verdonk Marinus Leendert
Saxty Gordon
Boyle Robert George
Berdini Valerio
Cancer Research Technology
The Institute Of Cancer Research Royal Cancer Hospital
Astex Therapeutics
IPC
C07D 487/04
C07D 473/34
C07D 473/00
C07D 471/04
A61K 31/519
A61K 31/437
A61K 31/52
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