WO/2006/012078 is referenced by 55 patents.

The present invention provides nucleoside aryl phosphoramidates which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.

Title
Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
Application Number
PCT/US2005/021684
Publication Number
2006/012078
Application Date
June 20, 2005
Publication Date
February 2, 2006
Inventor
Olsen David B
Maccoss Malcolm
Agent
MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907
Assignee
Olsen David B
Maccoss Malcolm
Merck & Co
IPC
C07H 19/00
A61K 31/70
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