WO/2005/123087 is referenced by 53 patents.

The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such C-nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the C-nucleoside compounds of the present invention.

Title
C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase
Application Number
PCT/US2005/020757
Publication Number
2005/123087
Application Date
June 10, 2005
Publication Date
December 29, 2005
Inventor
Eldrup Anne B
Bhat Balkrishen
Maccoss Malcolm
Butora Gabor
Agent
MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907
Assignee
Eldrup Anne B
Bhat Balkrishen
Maccoss Malcolm
Butora Gabor
Isis Pharmaceuticals
Merck & Co
IPC
A61K 31/70
A01N 43/04
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