WO/2005/115448 is referenced by 14 patents.

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25°C (and immunogenic compositions comprising the same) is also provided.

Title
Multi plasmid system for the production of influenza virus
Application Number
PCT/US2005/017734
Publication Number
2005/115448
Application Date
May 20, 2005
Publication Date
December 8, 2005
Inventor
Chen Zhongying
Kemble George
Duke Gregory
Lu bin
Jin Hong
Hoffmann Erich
Agent
ALBAN Patrick Scott
Assignee
Chen Zhongying
Kemble George
Duke Gregory
Lu bin
Jin Hong
Hoffmann Erich
Medimmune Vaccines
IPC
C12P 19/34
A61K 39/145
C12N 07/02
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