WO/2005/110411 is referenced by 5 patents.

The present invention concerns combinations comprising a compound of formula (I); the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters or metabolites thereof, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(=O), C(=O)OH, C1-4alkyloxyC(=O), C1-4 alkylC(=O), mono- or di(C1-4alkyl)aminoC(=O), arylaminoC(=O), N-(aryl)-N-(C1-4 alkyl)aminoC(=O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7 cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(=O), aminoC(=O), C1-4alkyloxyC(=O), mono- or di(C1-4alkyl)aminoC(=O), C1-4alkylC(=O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; and another HIV inhibitor. The invention also concerns products comprising a compound of formula (I) and another HIV inhibitor, as a combined preparation for simultaneous, separate or sequential use in treatment of retroviral infections such as HIV infection, in particular, in the treatment of infections with multi-drug resistant retroviruses.

Title
Combinations of substituted 1-phenyl-1,5-dihydro-pyrido- [3,2-b] indol-2-ones and other hiv inhibitors
Application Number
PCT/EP2005/052266
Publication Number
2005/110411
Application Date
May 17, 2005
Publication Date
November 24, 2005
Inventor
Surleraux Dominique Louis Nestor Ghislain
Tahri Abdellah
Wang Jing
Wigerinck Piet Tom Bert Paul
Jochmans Dirk Edward Désiré
Vroey Veronique Corine Paul
de
Bettens Eva
Hertogs Kurt
Canard Maxime Francis Jean Marie Ghislain
Kindermans Natalie Maria Francisca
Vreken Wim
Van de
Kesteleyn Bart Rudolf Romanie
Agent
WANTE Dirk
Assignee
Surleraux Dominique Louis Nestor Ghislain
Tahri Abdellah
Wang Jing
Wigerinck Piet Tom Bert Paul
Jochmans Dirk Edward Désiré
Vroey Veronique Corine Paul
de
Bettens Eva
Hertogs Kurt
Canard Maxime Francis Jean Marie Ghislain
Kindermans Natalie Maria Francisca
Vreken Wim
Van de
Kesteleyn Bart Rudolf Romanie
Tibotec Pharmaceuticals
IPC
A61P 31/18
A61P 31/12
A61K 45/06
A61K 31/5377
A61K 31/496
A61K 31/475
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