WO/2005/023782 is referenced by 10 patents.

(EN) A compound represented by the general formula (I): (I) [wherein A is phenyl, etc.; R1 is R1a (R1a is substituted alkyl, etc.), -Z1b-R1b (R1b is substituted alkyl, etc. and Z1b is -NH-, etc.), -Z1c-R1c (R1c has the same meaning as R1b or is alkyl and Z1c is -C≡C-, etc.), -N(R1b)(R1c), etc.; R2 and R3 each is hydrogen, optionally substituted alkyl, OH, etc.; R4 and R5 each is hydrogen, optionally substituted alkyl, OH, etc.; X is OH or alkoxy; and Y is optionally substituted alkyl, etc., provided that when Y is a specific group and A is phenyl, then R4 and R5 each is hydrogen and -C(CF3)2(X) is -C(CF3)2(OH) bonded to the phenyl group in the 3- or 4-position thereof] or a pharmacologically acceptable salt or ester of the compound. They are highly active in bonding to LXR and are useful as a medicine for warm-blooded animals (especially for the human), preferably as a medicine for treatments for and/or prevention of arteriosclerosis, hyperlipemia, inflammatory diseases, diabetes, etc.(JA) not available

Title
(Ja) 置換された縮環ピリミジン-4(3h)-オン化合物
(En) Substituted fused pyrimidine-4(3h)-one compound
Application Number
PCT/JP2004/013268
Publication Number
2005/023782
Application Date
September 6, 2004
Publication Date
March 17, 2005
Inventor
Oda Kozo
Watanabe Tsuyoshi
Shibuya Satoshi
Kaneko Satoru
Arai Masami
Agent
KUMAKURA Yoshio
Assignee
Oda Kozo
Watanabe Tsuyoshi
Shibuya Satoshi
Kaneko Satoru
Arai Masami
X Ceptor Therapeutics
Sankyo Company
IPC
A61K 31/541
A61K 31/5377
A61K 31/519
A61K 31/517
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