WO/2004/064826 is referenced by 37 patents.

One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. R1-R4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Preferably R1 and R2 are the same and R3 and R4 are the same. R5-R6 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. Z is =O or =S.

Title
Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer
Application Number
PCT/US2004/001089
Publication Number
2004/064826
Application Date
January 15, 2004
Publication Date
August 5, 2004
Inventor
Ono Mitsunori
Liang Guiqing
Tatsuta Noriaki
Chen Shoujun
Du Zhenjian
Zhou Dan
Korbut Timoty
Wu Yaming
Sun Lijun
Koya Keizo
Agent
DAVIS Steven G
Assignee
Ono Mitsunori
Liang Guiqing
Tatsuta Noriaki
Chen Shoujun
Du Zhenjian
Zhou Dan
Korbut Timoty
Wu Yaming
Sun Lijun
Koya Keizo
Synta Pharmaceuticals
IPC
A61K 31/277
A61K 31/165
A61K 31/16
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