WO/2004/007512 is referenced by 75 patents.

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Title
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
Application Number
PCT/US2003/021589
Publication Number
2004/007512
Application Date
July 11, 2003
Publication Date
January 22, 2004
Inventor
Prakash Thazha P
Olsen David B
Maccoss Malcolm
Eldrup Anne B
Carroll Steven S
Bhat Balkrishen
Agent
MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907
Assignee
Prakash Thazha P
Olsen David B
Maccoss Malcolm
Eldrup Anne B
Carroll Steven S
Bhat Balkrishen
Isis Pharmaceuticals
Merck & Co
IPC
C07H 19/14
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