WO/2003/102156 is referenced by 10 patents.

Methods and compositions to activate a genetically designated target cell (or population of targetcells) artificially, in vivo or in vitro, employ triggering of heterologous stimulus-gated ion channels to activate the cells. The stimulus-gated ion channels are suitably TRPV1, TRPM8 or P2X2. A stimuluswhich leads to opening or 'gating' of the ion channel can be a physical stimulus or a chemical stimulus.Physical stimuli can be provided by heat, or mechanical force, while chemical stimuli can suitably be a ligand, such as capsaicin for TRPV1 or ATP for P2X2, or a 'caged ligand,' for example a photolabileligand derivative, in which case a physical signal in the form of light is used to provide the chemical signal. Selective activation of the cell may be used for various applications including neuronal and neuroendocrine mapping and drug screening.

Title
Heterologous stimulus-gated ion channels and methods of using same
Application Number
PCT/US2003/017448
Publication Number
2003/102156
Application Date
June 2, 2003
Publication Date
December 11, 2003
Inventor
Zemelman Boris V
Miesenbock Gero A
Agent
LARSON Marina T
Assignee
Zemelman Boris V
Miesenbock Gero A
Sloan Kettering Institute For Cancer Research
IPC
G01N 33/68
C12N 05/06
C07K 14/705
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