Novel fused imidazole compounds of general formula (I), pharmacologically acceptable salts thereof, or hydrates of both, exhibiting adenosine A2 receptor antagonism and being effective in the prevention and treatment of diabetes mellitus and complications of diabetes; wherein R?1¿ is optionally alkylated amino or the like; R?2¿ is hydrogen, alkyl, or the like; R?3¿ is optionally substituted aryl, a pyridinone group, a pyrimidinone group, or the like; Ar is an optionally sybstituted aryl or heteroaryl group, or the like; and Q and W are each independently N or CH.

Title
Fused imidazole compounds and remedies for diabetes mellitus
Application Number
PCT/JP2000/004358
Publication Number
2001/002400
Application Date
June 30, 2000
Publication Date
January 11, 2001
Inventor
Naito Toshihiko
Negi Shigeto
Haga Toyokazu
Hayashi Kenji
Shimizu Toshikazu
Ozeki Naoki
Akamatsu Hirofumi
Shimomura Naoyuki
Kawata Tsutomu
Tanaka Isao
Kobayashi Seiichi
Murakami Manabu
Nagaoka Junsaku
Minami Hiroe
Oohashi Kaya
Yasuda Nobuyuki
Horizoe Tatsuo
Inoue Takashi
Watanabe Nobuhisa
Yoshikawa Seiji
Harada Hitoshi
Asano Osamu
Agent
FURUYA Kaoru
Assignee
Naito Toshihiko
Negi Shigeto
Haga Toyokazu
Hayashi Kenji
Shimizu Toshikazu
Ozeki Naoki
Akamatsu Hirofumi
Shimomura Naoyuki
Kawata Tsutomu
Tanaka Isao
Kobayashi Seiichi
Murakami Manabu
Nagaoka Junsaku
Minami Hiroe
Oohashi Kaya
Yasuda Nobuyuki
Horizoe Tatsuo
Inoue Takashi
Watanabe Nobuhisa
Yoshikawa Seiji
Harada Hitoshi
Asano Osamu
Eisai
IPC
C07D 473/40
C07D 473/34
C07D 473/00
C07D 471/04
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