WO/1999/032120 is referenced by 7 patents.

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step extraction process to be separated from the opioid agonist, the amount of opioid antagonist including being sufficient to counteract opioid effects if extracted together with the opioid agonist and administered parenterally.

Title
A method of preventing abuse of opioid dosage forms
Application Number
PCT/US1998/027258
Publication Number
1999/032120
Application Date
December 22, 1998
Publication Date
July 1, 1999
Inventor
Palermo Philip
Agent
DAVIDSON Clifford M
Assignee
Palermo Philip
Euro Celtique
IPC
A61K 31/485
A61K 31/44
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