Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.

Title
Novel burst-free sustained release poly-(lactide/glycolide) microspheres
Application Number
PCT/US1996/019440
Publication Number
1997/026869
Application Date
November 18, 1996
Publication Date
July 31, 1997
Inventor
Setterstrom Jean A
Mcqueen Charles E
Roberts F Donald
Reid Robert H
Friden Phil
Hamont John F
Van
Jeyanthi Ramasubbu
Agent
BELLAMY Werten F W
Assignee
Setterstrom Jean A
Mcqueen Charles E
Roberts F Donald
Reid Robert H
Friden Phil
Hamont John F
Van
Jeyanthi Ramasubbu
The Secretary Of The Army
Government Represented By
United States
IPC
A61K 09/16
A61K 38/17
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