3710795 is referenced by 368 patents and cites 8 patents.

Drug-delivery device for releasing drug at a controlled rate for a prolonged period of time is formed from a solid inner matrix material having drug dispersed therethrough. Surrounding the inner matrix is an intimately contacting outer polymeric membrane, insoluble in body fluids, which contracts about the matrix as the matrix decreases in volume upon drug release. Both the inner matrix material and the outer polymeric membrane are permeable to passage of the drug by diffusion but the drug diffuses through the outer polymer membrane at a lesser rate so that passage through the polymeric membrane is the drug release rate controlling step. The integrity of the intimate contact between the membrane and the matrix is assured even upon matrix depletion immediately following manufacture and for an extended period of time by reason of the reserve elastic recovery stress in the membrane.

Title
Drug-delivery device with stretched, rate-controlling membrane
Application Number
05/076,499
Publication Number
3710795
Application Date
September 29, 1970
Publication Date
January 16, 1973
Inventor
Leeper Harold M
Higuchi Takeru
Assignee
Alza Corporation
IPC
A61j 01/00
A61m 07/00
A61M 31/00
A61D 07/00
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