10172791 cites 29 patents.

Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Title
Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
Application Number
14/776639
Publication Number
10172791 (B2)
Application Date
March 14, 2014
Publication Date
January 8, 2019
Inventor
Arturo Jose Vegas
Cambridge
MA, US
Christian J Kastrup
Vancouver
CA
Delai Chen
Cambridge
MA, US
Joshua Charles Doloff
Quincy
MA, US
Omid Veiseh
Cambridge
MA, US
Robert S Langer
Newton
MA, US
Daniel G Anderson
Framingham
MA, US
Minglin Ma
Ithaca
NY, US
Agent
Pabst Patent Group
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61K 35/12
A61K 9/48
A61K 45/06
A61K 9/50
A61K 35/39
A61K 48/00
A61K 9/00
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