10167344 cites 201 patents.

A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that present a choice of two human light chain variable gene segments such that the immunoglobulin light chains expresses by the mouse comprise one of the two human light chain variable gene segments. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided.

Title
Mice expressing a limited immunoglobulin light chain repertoire
Application Number
15/700973
Publication Number
10167344 (B2)
Application Date
September 11, 2017
Publication Date
January 1, 2019
Inventor
Andrew J Murphy
Croton-on-Hudson
NY, US
Sean Stevens
Del Mar
CA, US
Lynn Macdonald
Harrison
NY, US
John McWhirter
Tarrytown
NY, US
Agent
Stephanie L Schonewald
Brenda Herschbach Jarrell
Choate Hall & Stewart
Assignee
Regeneron Pharmaceuticals
NY, US
IPC
C07K 16/00
C12N 15/85
C07K 16/46
C12N 15/87
C12N 15/13
C12N 5/10
C12N 5/071
A01K 67/027
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