10143186 cites 211 patents.

A genetically modified mouse is provided, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable sequence, wherein the mouse expresses only one or two human light chain variable domains encoded by human immunoglobulin sequences operably linked to the mouse kappa (κ) constant gene at the endogenous mouse κ locus, wherein the mouse expresses a reverse chimeric antibody having a light chain variable domain derived from one of only two human light chain variable region gene segments and a mouse κ constant domain, and a human heavy chain variable domain and a mouse heavy chain constant domain, from an endogenous mouse heavy chain locus. Bispecific epitope-binding proteins that are fully human are provided, comprising two different heavy chains that associate with an identical light chain that comprises a variable domain derived from one of two different human light chain variable region gene segments.

Title
Common light chain mouse
Application Number
13/22759
Publication Number
10143186 (B2)
Application Date
February 8, 2011
Publication Date
December 4, 2018
Inventor
Andrew J Murphy
Croton-on-Hudson
NY, US
David R Buckler
Sleepy Hollow
NY, US
Sean Stevens
Del Mar
CA, US
Lynn Macdonald
Harrison
NY, US
John McWhirter
Tarrytown
NY, US
Agent
Stephanie L Schonewald
Brenda Herschbach Jarrell
Choate Hall & Stewart
Assignee
Regeneron Pharmaceuticals
NY, US
IPC
C07K 16/22
C12N 15/90
C12N 15/85
C07K 16/28
C07K 16/00
C07K 16/46
A01K 67/027
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