10130081 cites 290 patents.

Mice, tissues, cells, and genetic material are provided that comprise a humanized heavy chain immunoglobulin locus, a humanized light chain locus that expresses a universal light chain, and a gene encoding an ADAM6 or ortholog or homolog or functional fragment thereof. Mice are provided that express humanized heavy chains comprising human variable domains, and that express humanized light chains comprising human variable domains wherein the light chains are derived from no more than one, or no more than two, light chain V and J or rearranged V/J sequences. Fertile male mice that express antibodies with universal light chains and humanized heavy chains are provided. Methods and compositions for making bispecific binding proteins are provided.

Title
Humanized universal light chain mice
Application Number
13/566765
Publication Number
10130081 (B2)
Application Date
August 3, 2012
Publication Date
November 20, 2018
Inventor
Margaret Karow
Santa Rosa
CA, US
Andrew J Murphy
Croton-on-Hudson
NY, US
Sean Stevens
Del Mar
CA, US
Lynn MacDonald
Harrison
NY, US
John McWhirter
Hastings-on-Hudson
NY, US
Agent
Stephanie L Schonewald
Brenda Herschbach Jarrell
Choate Hall & Stewart
Assignee
Regeneron Pharmaceuticals
NY, US
IPC
C12N 9/64
C07K 16/40
C07K 16/28
C12N 5/10
C07K 16/00
C12N 15/85
A01K 67/027
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