09969814 cites 215 patents.

A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.

Title
Methods for making fully human bispecific antibodies using a common light chain
Application Number
14/473970
Publication Number
9969814 (B2)
Application Date
August 29, 2014
Publication Date
May 15, 2018
Inventor
Andrew J Murphy
Croton-on-Hudson
NY, US
Sean Stevens
Del Mar
CA, US
Lynn MacDonald
Harrison
NY, US
John McWhirter
Hastings-on-Hudson
NY, US
Agent
Stephanie L Schonewald
Brenda Herschbach Jarrell
Choate Hall & Stewart
Assignee
Regeneron Pharmaceuticals
NY, US
IPC
C07K 16/28
C12N 15/85
C07K 16/00
C12N 15/90
C07K 16/46
A01K 67/027
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