09969689 cites 65 patents.

The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.

Title
Aryl ethers and uses thereof
Application Number
15/439308
Publication Number
9969689 (B2)
Application Date
February 22, 2017
Publication Date
May 15, 2018
Inventor
Hanbiao Yang
Coppell
TX, US
Rui Xu
Dallas
TX, US
Paul Wehn
Dallas
TX, US
Bin Wang
Dallas
TX, US
Eli M Wallace
Richardson
TX, US
Stephen T Schlachter
Dallas
TX, US
James P Rizzi
Irving
TX, US
John A Josey
Dallas
TX, US
Jonas Grina
Coppell
TX, US
Darryl David Dixon
Somerset
NJ, US
Agent
Wilson Sonsini Goodrich & Rosati
Assignee
PELOTON THERAPEUTICS
TX, US
IPC
C07D 213/65
C07C 317/22
C07D 213/85
A61K 31/09
C07C 43/275
C07C 43/29
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