A surgical stapling system for treating the tissue of a patient is provided. Various embodiments of the surgical stapling system include a handle including a rotary motion generator, a shaft extending from the handle, and a disposable loading unit attachable to the shaft. The disposable loading unit includes a cartridge body including a distal end, staples removably stored in the cartridge body, and a firing system. The firing system includes a cutting portion configured to cut the tissue. The disposable loading unit includes a lockout configured to block the firing system from moving toward the distal end. The surgical stapling system includes an actuation system configured to regulate a force applied to the firing system.