09850520 cites 18 patents.

An electrochemical method for measuring the activity of enzymes using nanoelectrode arrays fabricated with vertically aligned carbon nanofibers. Short peptide substrates specific to disease-related enzymes are covalently attached to the exposed nanofiber tips. A redox moiety, such as ferrocene, can be linked at the distal end of the nanofibers. Contact of the arrays with a biological sample containing one or more target enzymes results in cleavage of the peptides and changes the redox signal of the redox moiety indicating the presence of the target enzymes.

Title
Electrochemical detection of proteases using AC voltammetry on nanoelectrode arrays
Application Number
14/320215
Publication Number
9850520 (B2)
Application Date
June 30, 2014
Publication Date
December 26, 2017
Inventor
Luxi Swisher
Manhattan
KS, US
Allan Prior
Manhattan
KS, US
Lateef Uddin Syed
Portland
OR, US
Duy Hua
Manhattan
KS, US
Jun Li
Manhattan
KS, US
Agent
Hovey Williams
Assignee
Kansas State University Research Foundation
KS, US
IPC
B82Y 15/00
G01N 27/30
G01N 27/27
B01J 19/00
C12Q 1/37
G01N 33/48
G01N 33/00
G01N 15/06
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