09828420 is referenced by 1 patents and cites 180 patents.

Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.

Title
Method of providing disease-specific binding molecules and targets
Application Number
15/66304
Publication Number
9828420 (B2)
Application Date
March 10, 2016
Publication Date
November 28, 2017
Inventor
Jan Grimm
Deubendorf
CH
Kathrin Tissot
Neuried
DE
Marlen Knobloch
Tolochenaz
CH
Christoph Esslinger
Zurich
CH
Christoph Hock
Erlenbach
CH
Roger Nitsch
Zumikon
CH
Agent
Fish & Richardson P C
Assignee
University of Zürich
CH
IPC
A61K 39/00
G01N 33/68
A61K 45/06
A61K 51/10
C07K 16/18
C07K 16/00
A61K 39/395
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