Presented herein is a modular analyte measurement system having a replaceable strip port module that releasably connects and operably couples with an analyte meter. Embodiments of the present invention also relate to modular components of the analyte measurement system. In one aspect, there is provided a replaceable strip port module having a strip port and electrical interface for removably and electrically coupling with an analyte meter. In another aspect, there is provided an analyte meter that includes a processor and electrical interface for removably and electrically coupling with replaceable strip port modules. Methods of configuring the analyte measurement system and methods of determining an analyte meter with the analyte measurement system are also provided.