09624281 cites 97 patents.

In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess iron from the body, for example in the treatment of iron overload. The NGAL mutants of the invention also have antibacterial activity and can be used in the treatment of bacterial infections, such as those of the urinary tract.

Title
Mutant NGAL proteins and uses thereof
Application Number
14/719204
Publication Number
9624281 (B2)
Application Date
May 21, 2015
Publication Date
April 18, 2017
Inventor
Andong Qiu
Bronx
NY, US
Jonathan Barasch
New York
NY, US
Agent
Wilmer Cutler Pickering Hale and Dorr
Assignee
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
NY, US
IPC
C07K 14/47
A61K 38/00
A61K 35/74
C12N 15/03
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