09566326 cites 24 patents.

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence of high serum antibody titers and also longer seroconversion and seroprotection. The improvement in immune responses is seen for both influenza A virus and influenza B virus strains, but it is particularly marked for influenza B virus. Moreover, while the existing vaccine provides poor immunity in children after a single dose, the adjuvanted vaccine provides high seroprotection rates against the influenza A virus H3N2 subtype even after a single dose. Furthermore, the adjuvanted vaccine offers significantly better seroprotection against mismatched strains of influenza A virus.

Title
Adjuvanted influenza vaccines for pediatric use
Application Number
13/923642
Publication Number
9566326 (B2)
Application Date
June 21, 2013
Publication Date
February 14, 2017
Inventor
Michele Pellegrini
Castelnuovo Berardenga
IT
Nicola Groth
Buonconvento
IT
Audino Podda
Sovicille
IT
Agent
Finnegan Henderson Farabow Garrett & Dunner
Assignee
Seqirus
GB
IPC
A61K 39/39
A61K 39/00
A61K 39/12
A61K 39/145
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