09550838 cites 139 patents.

Disclosed herein are methods and compositions dock and lock (DNL) complexes comprising an AD moiety selected from an AKAP protein and a DDD moiety selected from a protein kinase A regulatory subunit. Also disclosed are fusion proteins comprising an AD moiety or DDD moiety attached to an effector moiety. The DDD moieties form dimers that bind to the AD moiety to form the DNL complexes. The effector moieties may be selected from a wide range of known effector moieties that produce one or more physiological effects, including but not limited to cell death. The DNL complexes may further comprise one or more diagnostic and/or therapeutic agents. The DNL complexes are of use for treating and/or diagnosing a variety of diseases or conditions.

Title
Dock-and-lock (DNL) complexes for therapeutic and diagnostic use
Application Number
14/503973
Publication Number
9550838 (B2)
Application Date
October 1, 2014
Publication Date
January 24, 2017
Inventor
David M Goldenberg
Mendham
NJ, US
Chien Hsing Chang
Downingtown
PA, US
Agent
Richard A Nakashima
Assignee
IBC Pharmaceuticals
NJ, US
IPC
C12N 9/12
C07K 14/47
A61K 51/10
A61K 51/08
C07K 16/46
C07K 16/44
C07K 16/30
C07K 16/28
A61K 47/48
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