09526763 is referenced by 3 patents and cites 709 patents.

A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

Title
Solvent/polymer solutions as suspension vehicles
Application Number
14/749178
Publication Number
9526763 (B2)
Application Date
June 24, 2015
Publication Date
December 27, 2016
Inventor
Stan Lam
Dublin
CA, US
Pauline Zamora
Sausalito
CA, US
Michael A Desjardin
Aptos
CA, US
Paul R Houston
Hayward
CA, US
Rupal A Ayer
Cupertino
CA, US
Andrew S Luk
Castro Valley
CA, US
Guohua Chen
Sunnyvale
CA, US
Catherine M Rohloff
Los Altos
CA, US
Agent
Cooley
Assignee
Intarcia Therapeutics
MA, US
IPC
A61K 47/26
A61K 47/20
A61K 47/02
A61K 47/14
A61K 47/12
A61K 38/36
A61K 38/35
A61K 38/31
A61K 38/28
A61K 38/27
A61K 38/26
A61K 38/24
A61K 38/22
A61K 38/19
A61K 38/11
A61K 38/18
A61K 38/10
A61K 38/09
A61K 38/04
A61K 38/08
A61K 38/21
A61K 47/10
A61K 47/32
A61K 9/00
A61K 9/10
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