Tissue collection systems and methods are provided. More particular, a modular system including one or more manifold elements is provided. Each manifold element includes a manifold barrel and a coupler to which a syringe body can be connected. An inlet of a first manifold element is connected to a first manifold cap having an inlet orifice. A second manifold cap having an outlet orifice is connected to the outlet of the first manifold element or to the outlet of a second manifold element. The manifold barrel can include a barrel inlet that is offset from a barrel outlet.