09428535 is referenced by 1 patents and cites 1391 patents.

The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.

Title
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
Application Number
13/644072
Publication Number
9428535 (B2)
Application Date
October 3, 2012
Publication Date
August 30, 2016
Inventor
Stephane Bancel
Boston
MA, US
Paul Hatala
Charlestown
MA, US
Suhaib Siddiqi
Burlington
MA, US
Jason P Schrum
Philadelphia
PA, US
Atanu Roy
Stoneham
MA, US
Antonin de Fougerolles
Brookline
MA, US
Agent
Clark & Elbing
Assignee
Moderna Therapeutics
MA, US
IPC
A61K 48/00
C12N 15/67
C07H 21/02
C12N 15/11
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