09332742 cites 122 patents.

A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses human immunoglobulin light chain variable domains derived from a limited repertoire of human immunoglobulin light chain variable gene segments that comprise histidine modifications in their germline sequence. Methods of making non-human animals that express antibodies comprising histidine residues encoded by histidine codons introduced into immunoglobulin light chain nucleotide sequences are provided.

Title
Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same
Application Number
14/705916
Publication Number
9332742 (B2)
Application Date
May 6, 2015
Publication Date
May 10, 2016
Inventor
Andrew J Murphy
Croton-on-Hudson
NY, US
Lynn MacDonald
White Plains
NY, US
John McWhirter
Tarrytown
NY, US
Agent
Margarita Zippin
Rita S Wu
Brownstein Hyatt Farber Schreck
Assignee
Regeneron Pharmaceuticals
NY, US
IPC
C12N 15/85
C07K 16/00
A01K 67/027
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