09301510 is referenced by 1 patents and cites 117 patents.

Genetically modified non-human animals are provided that comprise an immunoglobulin heavy chain locus comprising an unrearranged human heavy chain variable region nucleotide sequence comprising an addition of at least one histidine codon or a substitution of at least one endogenous non-histidine codon with a histidine codon. Compositions and methods for making the genetically modified non-human animals as described herein are provided. Non-human animals capable of expressing an antigen-binding protein characterized by pH-dependent antigen binding, enhanced recyclability and/or enhanced serum half-life are also provided.

Title
Mice that produce antigen-binding proteins with pH-dependent binding characteristics
Application Number
13/832309
Publication Number
9301510 (B2)
Application Date
March 15, 2013
Publication Date
April 5, 2016
Inventor
Andrew J Murphy
Croton-on-Hudson
NY, US
Lynn MacDonald
White Plains
NY, US
John McWhirter
Tarrytown
NY, US
Agent
Yong Jin Choi
Rita S Wu
Brownstein Hyatt Farber Schneck
Assignee
Regeneron Pharmaceuticals
NY, US
IPC
C12N 15/85
C07K 16/00
A01K 67/027
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