Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.

Title
Boronic acid bearing liphagane compounds as inhibitors of P13K-α and/or β
Application Number
14/385808
Publication Number
9206201 (B2)
Application Date
March 18, 2013
Publication Date
December 8, 2015
Inventor
Nayan Chanauria
Jammu
IN
Aashiq Hussain
Jammu
IN
Asif Khurshid Qazi
Jammu
IN
Ramesh Mudududdla
Jammu
IN
Anjaneya Aravind Kumar Kolluru
Jammu
IN
Amit Nargotra
Jammu
IN
Ajit Kumar Saxena
Jammu
IN
Parduman Raj Sharma
Jammu
IN
Abid Hamid Dar
Jammu
IN
Parvinder Pal Singh
Jammu
IN
Sanghapal Damodhar Sawant
Jammu
IN
Ram Asrey Vishwakarma
Jammu
IN
Agent
McDonald Hopkins
Assignee
Counsel of Scientific & Industrial Research
IN
IPC
A61K 31/69
C07F 5/02
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