09109010 is referenced by 7 patents and cites 180 patents.

Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.

Title
Viral inactivation during purification of antibodies cross reference to related applications
Application Number
12/582556
Publication Number
9109010 (B2)
Application Date
October 20, 2009
Publication Date
August 18, 2015
Inventor
Ivan R Correia
Winchester
MA, US
Robert K Hickman
Worcester
MA, US
Agent
Foley Hoag
Assignee
AbbVie
IL, US
IPC
C07K 1/16
C07K 1/18
C07K 1/14
C07K 1/36
C07K 17/00
C07K 16/00
C07K 14/16
C07K 1/00
A23J 1/00
View Original Source