09018361 is referenced by 7 patents and cites 175 patents.

Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.

Title
Isolation and purification of antibodies using protein a affinity chromatography
Application Number
14/226636
Publication Number
9018361 (B2)
Application Date
March 26, 2014
Publication Date
April 28, 2015
Inventor
Min Wan
Frederick
MD, US
Barbara Perilli Palmer
Bolton
MA, US
Scott T Ennis
South Grafton
MA, US
Cheryl L Weed
Scituate
RI, US
Qing Huang
Singapore
SG
Robert K Hickman
Worcester
MA, US
Agent
Foley Hoag
Assignee
AbbVie
IL, US
IPC
C07K 16/00
C07K 1/16
C07K 16/24
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