09011879 is referenced by 22 patents and cites 98 patents.

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict medication regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

Treatment of renal hypertension or carotid sinus syndrome with heated fluid sympathetic denervation or neuromodulation
Application Number
Publication Number
9011879 (B2)
Application Date
May 16, 2013
Publication Date
April 21, 2015
Kirk Patrick Seward
San Francisco
Wilson Sonsini Goodrich & Rosati
Mercator MedSystems
A61M 5/44
A61M 5/00
A61M 25/10
A61K 31/395
A61K 31/155
A61K 9/00
A61K 45/06
A61K 47/00
A61M 25/00
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