09006487 is referenced by 9 patents and cites 190 patents.

Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

Title
Amine-containing lipids and uses thereof
Application Number
11/453222
Publication Number
9006487 (B2)
Application Date
June 14, 2006
Publication Date
April 14, 2015
Inventor
Michael Goldberg
Cambridge
MA, US
Robert S Langer
Newton
MA, US
Elizaveta Sergeyevna Leshchiner
Watertown
MA, US
Andreas Zumbuehl
Cambridge
MA, US
Daniel G Anderson
Framingham
MA, US
Agent
Wei Zhang
C Hunter Baker
Wolf Greenfield & Sacks P C
Assignee
Massachusetts Institute of Technology
MA, US
IPC
C07D 317/28
C07D 307/14
C07D 295/12
C07D 243/08
C07D 233/61
C07D 211/26
C07C 237/06
C07C 229/18
C07C 229/16
C07C 229/14
C07C 229/12
A61K 9/16
A61K 48/00
G01N 33/92
C07B 53/00
A61K 31/785
C12N 15/88
C07C 229/00
C07C 239/00
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