08993779 is referenced by 1 patents and cites 13 patents.

The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.

Title
Positive allosteric modulators of MGLUR2
Application Number
13/814870
Publication Number
8993779 (B2)
Application Date
August 5, 2011
Publication Date
March 31, 2015
Inventor
Joseph E Pero
Harleysville
PA, US
Kevin J Rodzinak
Schwenksville
PA, US
Alexander J Reif
Holland
PA, US
Mark E Layton
Harleysville
PA, US
Kenneth L Arrington
Revere
MA, US
Mark E Fraley
North Wales
PA, US
Vadim Y Dudkin
Lansdale
PA, US
Agent
John C Todaro
Keith D MacMillan
Assignee
Merck Sharp & Dohme
NJ, US
IPC
C07D 471/04
C07D 413/10
C07D 409/10
C07D 405/10
C07D 513/14
C07D 453/02
C07D 405/06
C07D 403/10
C07D 401/12
C07D 401/10
C07D 401/06
C07D 401/14
C07D 401/04
C07D 403/14
C07D 403/04
C07D 417/14
C07D 235/26
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