08980865 is referenced by 5 patents and cites 434 patents.

Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.

Title
Substituted nucleotide analogs
Application Number
13/722472
Publication Number
8980865 (B2)
Application Date
December 20, 2012
Publication Date
March 17, 2015
Inventor
Leonid Beigelman
San Mateo
CA, US
Guangyi Wang
Carlsbad
CA, US
Agent
Knobbe Martens Olson & Bear
Assignee
Alios BioPharma
CA, US
IPC
C07H 19/207
A61K 45/06
A61K 38/21
A61K 31/708
A61K 31/7076
A61K 31/7056
A61K 31/7072
C07H 19/048
C07H 19/10
C07H 19/20
C07H 19/00
C07H 19/04
A61K 31/70
A01N 43/04
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