08940316 is referenced by 6 patents and cites 115 patents.

A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide, wherein the peptide is dispersed in the vehicle. The particle formulation further includes a stabilizing component comprising one or more stabilizers, for example, carbohydrates, antioxidants, amino acids, and buffers. Devices for delivering the suspension formulations and methods of use are also described.

Title
Osmotic delivery comprising an insulinotropic peptide and uses thereof
Application Number
12/927432
Publication Number
8940316 (B2)
Application Date
November 15, 2010
Publication Date
January 27, 2015
Inventor
Bing Yang
Redwood City
CA, US
Catherine M Rohloff
Los Altos
CA, US
Ryan D Mercer
Dublin
CA, US
Thomas R Alessi
Hayward
CA, US
Agent
Ivor Elrifi
Cooley
Assignee
Intarcia Therapeutics
MA, US
IPC
C07K 14/605
C07K 7/06
A61K 47/14
A61K 9/70
A61K 9/16
A61K 9/10
A61K 9/00
A61P 3/10
A61K 38/26
A61F 2/00
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