08911964 is referenced by 30 patents and cites 209 patents.

The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.

Title
Fed-batch method of making human anti-TNF-alpha antibody
Application Number
14/226579
Publication Number
8911964 (B2)
Application Date
March 26, 2014
Publication Date
December 16, 2014
Inventor
Thomas Seewoester
Simi Valley
CA, US
Yu Hsiang David Chang
Solana Beach
CA, US
James McIntire
Castro Valley
CA, US
David F Bruton
Enfield
CT, US
Nichole A Roy
Worcester
MA, US
Christof Schulz
Ayer
MA, US
John C Fann
Shrewsbury
MA, US
Joseph G Matuck
Worcester
MA, US
Itzcoatl A Pla
Worcester
MA, US
Agent
Foley Hoag
IPC
C07K 16/24
C12N 5/02
C12N 5/00
C12N 5/10
C12N 5/16
C12N 5/07
C12P 21/04
G01N 33/48
G01N 1/30
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