08895709 is referenced by 27 patents and cites 166 patents.

Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.

Title
Isolation and purification of antibodies using protein A affinity chromatography
Application Number
12/582506
Publication Number
8895709 (B2)
Application Date
October 20, 2009
Publication Date
November 25, 2014
Inventor
Min Wan
Frederick
MD, US
Barbara Perilli Palmer
Bolton
MA, US
Scott T Ennis
Worcester
MA, US
Cheryl L Weed
Scituate
RI, US
Qing Huang
Worcester
MA, US
Robert K Hickman
Worcester
MA, US
Agent
Foley Hoag
Assignee
AbbVie
IL, US
IPC
A61K 39/395
C07K 16/24
C07K 16/00
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