08895307 is referenced by 26 patents and cites 13 patents.

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Title
Ketol-acid reductoisomerase using NADH
Application Number
13/550565
Publication Number
8895307 (B2)
Application Date
July 16, 2012
Publication Date
November 25, 2014
Inventor
Daniel P Okeefe
Ridley Park
PA, US
Mark J Nelson
Newark
DE, US
Der Ing Liao
Wilmington
DE, US
Yougen Li
Lawrenceville
NJ, US
Assignee
Butamax Advanced Biofuels
DE, US
IPC
C12P 7/16
C12N 9/04
C07H 21/04
C12N 1/20
C12N 9/02
C12N 15/00
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