08853199 is referenced by 7 patents and cites 110 patents.

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Title
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
Application Number
13/272079
Publication Number
8853199 (B2)
Application Date
October 12, 2011
Publication Date
October 7, 2014
Inventor
Steven Do
San Jose
CA, US
Christine Chabot
San Mateo
CA, US
Birong Zhang
Union City
CA, US
Brian Safina
Redwood City
CA, US
Jun Liang
Palo Alto
CA, US
Anna L Banka
Longmont
CO, US
Stephen T Schlachter
Boulder
CO, US
Eli M Wallace
Lyons
CO, US
Josef R Bencsik
Longmont
CO, US
Keith Lee Spencer
Lyons
CO, US
Dengming Xiao
Longmont
CO, US
Nicholas C Kallan
Boulder
CO, US
Rui Xu
Longmont
CO, US
James F Blake
Longmont
CO, US
Ian S Mitchell
Lafayette
CO, US
Agent
Viksnins Harris & Padys PLLP
Assignee
Genentech
CA, US
Array Biopharma
CO, US
IPC
C07D 239/70
A61P 25/28
A61P 29/00
A61P 35/00
A61K 31/496
C07D 413/12
C07D 405/12
C07D 401/12
C07D 403/12
C07D 409/14
C07D 409/12
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