08808740 is referenced by 15 patents and cites 291 patents.

In certain embodiments, the present invention is directed to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid analgesic dispersed in a first matrix material; and a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material; wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37 C.

Title
Encased tamper resistant controlled release dosage forms
Application Number
13/333560
Publication Number
8808740 (B2)
Application Date
December 21, 2011
Publication Date
August 19, 2014
Inventor
Haiyong Hugh Huang
Princeton
NJ, US
Agent
Lowenstein Sandler
Assignee
Purdue Pharma
CT, US
IPC
A61K 9/24
A61K 9/20
A61K 31/485
A61K 9/28
A61K 9/26
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