08697421 is referenced by 4 patents and cites 137 patents.

The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.

Title
Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
Application Number
13/615168
Publication Number
8697421 (B2)
Application Date
September 13, 2012
Publication Date
April 15, 2014
Inventor
John D Trawick
San Diego
CA, US
Anthony P Burgard
Bellefonte
PA, US
Christophe H Schilling
San Diego
CA, US
Mark J Burk
San Diego
CA, US
Agent
Jones Day
Assignee
Genomatica
CA, US
IPC
C07H 21/04
C12P 19/32
C12P 5/02
C12P 7/26
C12P 11/00
C12N 1/00
C12N 1/20
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